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Hydroquinone (HQ), another well-studied whitening agent, has been used clinically in leading cosmetic hyperpigmentation treatment 23 , however, it was also found to cause serious problems by generating reactive oxygen species leading to oxidative damage of lipids and permanent loss of melanocytes

Autophagy contributes to cell survival by dismantling dysfunctional mitochondria and decreasing ROS levels, a process contingent upon the hypoxia-induced expression of HIF-1, which involves the HIF-1/BNIP3 signaling pathway (94)

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BPC-157s protective effects shield esophageal tissue from these additional insults while promoting healing of existing damage

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